Lobaric acid [522-53-2]

MedChem Express

Lobaric acid [522-53-2]

5

522-53-2

Research Use Only

C25H28O8

456.49

Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals (IC50=97.9 microM) and inhibits cancer cell proliferation (EC50 of 15.2-63.9 microg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 microM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase (IC50=28.5 microM). Lobaric acid (250 microM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus (TMV).

O=C(C1=C(O)C=C(C(OC2=CC(OC)=CC(C(CCCC)=O)=C23)=C1CCCCC)OC3=O)O

12352200