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ProductsBack/Lofepramine (hydrochloride) [26786-32-3]

Lofepramine (hydrochloride) [26786-32-3]

HY-12390A

CAS Number26786-32-3

Product group Chemicals

Molecular Weight455.42

Overview

Supplier
MedChem Express
Product Name
Lofepramine (hydrochloride) [26786-32-3]
Delivery Days Customer
10
CAS Number
26786-32-3
Certification
Research Use Only
Hazard Information
h225-h290-h301+h311+h331-h370,p210-p233-p234-p240-p241-p242-p243-p260-p261-p264-p270-p271-p280-p302+p352-p304+p340-p330-p361+p364-p370+p378-p390-p405-p406-p501
Molecular Formula
C26H28Cl2N2O
Molecular Weight
455.42
Scientific Description
Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and 5-hydroxytryptamine (5-HT) with IC50s of 2.7 microM and 11 microM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. [1][2][3][4].
SMILES
CN(CC(C1=CC=C(Cl)C=C1)=O)CCCN2C3=CC=CC=C3CCC4=CC=CC=C42.Cl
UNSPSC
12352200

MSDS

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