Lopinavir

MedChem Express

Lopinavir [192725-17-0]

10

192725-17-0

Research Use Only

99.97

C37H48N4O5

628.80

Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease , with K i s of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity [1] [2] . Lopinavir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 14.2 microM [3] .

CC1=C(OCC(N[C@@H](CC2=CC=CC=C2)[C@@H](O)C[C@H](CC3=CC=CC=C3)NC([C@H](C(C)C)N4C(NCCC4)=O)=O)=O)C(C)=CC=C1

-20°C,2°C to 8°C

12352200