Losartan Carboxylic Acid

MedChem Express

Losartan Carboxylic Acid [124750-92-1]

10

124750-92-1

Research Use Only

99.77

C22H21ClN6O2

436.89

Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure [1] [2] [3] [4] .

O=C(C1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2)O

-20°C,2°C to 8°C

12352200