LOX-1 Protein, Mouse, Recombinant (His)

TargetMol Chemicals

LOX-1 Protein, Mouse, Recombinant (His)

16

Research Use Only

36.1 kDa (predicted). Due to glycosylation, the protein migrates to 55-63 kDa based on Tris-Bis PAGE result.

LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and related disorders. In this article we focus on the different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis.

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