Loxoribine [121288-39-9]

AdipoGen Life Sciences

Loxoribine

10

121288-39-9

Research Use Only

>97%

C13H17N5O6

339.3

Chemical. CAS: 121288-39-9. Formula: C13H17N5O6. MW: 339.3. Guanosine analog derivatized at position N7 and C8. Very potent immunostimulatory compound that increases cytokine production. Antitumor and antiviral activity compound. Potent and selective synthetic ligand for Toll-like receptor 7 (TLR7). Co-incubation with thymidine homopolymer oligodeoxynucleotides (ODN) redirected the stimulatory effect of loxoribine away from TLR7 toward TLR8. Induces autophagy and autophagy-induced cell death in Caco-2 cells. Shows adjuvant activity to increase the effectiveness of vaccines. - Guanosine analog derivatized at position N7 and C8 [1]. Very potent immunostimulatory compound that increases cytokine production [2-5]. Antitumor and antiviral activity compound [5, 6, 7, 12]. Potent and selective synthetic ligand for Toll-like receptor 7 (TLR7) [7-10]. Co-incubation with thymidine homopolymer oligodeoxynucleotides (ODN) redirected the stimulatory effect of loxoribine away from TLR7 toward TLR8 [11]. Induces autophagy and autophagy-induced cell death in Caco-2 cells [12]. Shows adjuvant activity to increase the effectiveness of vaccines [4].

NC1=NC2=C(N(CC=C)C(=O)N2[C@@H]2O[C@H](CO)C(O)[C@@H]2O)C(=O)N1

-20°C,2°C to 8°C

12352200