LP-922761

MedChem Express

LP-922761 [1454808-95-7]

10

1454808-95-7

Research Use Only

98.21

C21H26N6O3

410.47

LP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic alpha2 or GABAa receptors[1].

O=C(N(C)CCNC1=NN2C(C=C1)=NC=C2C3=CC=C(C=C3)C(N)=O)OC(C)(C)C

-20°C,2°C to 8°C

12352200