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ProductsBack/LRP6 Antibody

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA013102ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA013102ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA013102ESR2HU at dilution of 1:100

LRP6 Antibody

CSB-PA013102ESR2HU

ApplicationsELISA, ImmunoHistoChemistry

Product group Antibodies

ReactivityHuman

TargetLRP6

Overview

Supplier
Cusabio
Product Name
LRP6 Antibody
Delivery Days Customer
20
Applications
ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID4040
Target name
LRP6
Target description
LDL receptor related protein 6
Target synonyms
ADCAD2; low-density lipoprotein receptor-related protein 6; LRP-6; STHAG7
Host
Rabbit
Isotype
IgG
Protein IDO75581
Protein Name
Low-density lipoprotein receptor-related protein 6
Scientific Description
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
Reactivity
Human
Storage Instruction
-20°C or -80°C
UNSPSC
41116161

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