LS-104 [368836-72-0]
HY-118084
CAS Number368836-72-0
Product group Chemicals
Molecular Weight320.34
Overview
- SupplierMedChem Express
- Product NameLS-104 [368836-72-0]
- Delivery Days Customer9
- CAS Number368836-72-0
- CertificationResearch Use Only
- Molecular FormulaC19H16N2O3
- Molecular Weight320.34
- Scientific DescriptionLS-104 (Tyrene CR-4) is a non-ATP-competitive kinase inhibitor against JAK2, Bcr-Abl and FLT3. LS-104 potently induces apoptosis in JAK2V617F-positive cells and inhibits JAK2 autophosphorylation and downstream signal transduction. LS-104 also inhibits proliferation and induces potent cytotoxic effects in FLT3 expressing leukemic cells. LS-104 is a hydroxystyryl-acrylonitrile compound, which is promising for research of myeloproliferative disorders and refractory/relapsed hematologic malignancies[1][2].
- SMILESOC1=C(O)C=CC(/C=C/C=C(C#N)/C(NCC2=CC=CC=C2)=O)=C1
- UNSPSC12352200