LTbetaR (mouse):Fc (human) (rec.)

AdipoGen Life Sciences

LTbetaR (mouse):Fc (human) (rec.)

2

Research Use Only

1 mg/ml

>95%

Ltbr

lymphotoxin B receptor

LTbetaR, Ltar, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFRrp, Tnfbr, Tnfrsf3, tumor necrosis factor receptor superfamily member 3, LT-beta receptor, TNF receptor-related protein, lymphotoxin-beta receptor

Tumor necrosis factor receptor superfamily member 3

Lymphotoxin beta receptor (LTbetaR) belongs to the tumor necrosis factor receptor superfamily (TNFR) and is a key regulator of lymphoid organogenesis and inflammation. LTbetaR is primarily expressed by epithelial cells, dendritic cells (DCs), stromal cells and macrophages. LTbetaR interacts with two ligands: membrane heterotrimeric lymphotoxin LTalpha1beta2 (LT) and homotrimeric LIGHT, both expressed predominantly by activated lymphoid cells. LTbetaR signaling can activate both canonical and alternative NF-kB signaling to induce various proinflammatory chemokines and cytokines and promote apoptosis via TRAF3 and TRAF5. LTbetaR also plays a role in the development of lymphoid organs. LTbetaR (mouse):Fc treatment partially impairs the structure of secondary lymphoid organs and shows therapeutic efficacy in various models of inflammatory diseases. - Recombinant Protein. The extracellular domain of mouse LTbetaR (aa 31-217) is fused at the C-terminus to the Fc portion of human IgG1. Lyophilized. Contains PBS. Lymphotoxin beta receptor (LTbetaR) belongs to the tumor necrosis factor receptor superfamily (TNFR) and is a key regulator of lymphoid organogenesis and inflammation. LTbetaR is primarily expressed by epithelial cells, dendritic cells (DCs), stromal cells and macrophages. LTbetaR interacts with two ligands: membrane heterotrimeric lymphotoxin LTalpha1beta2 (LT) and homotrimeric LIGHT, both expressed predominantly by activated lymphoid cells. LTbetaR signaling can activate both canonical and alternative NF-kB signaling to induce various proinflammatory chemokines and cytokines and promote apoptosis via TRAF3 and TRAF5. LTbetaR also plays a role in the development of lymphoid organs. LTbetaR (mouse):Fc treatment partially impairs the structure of secondary lymphoid organs and shows therapeutic efficacy in various models of inflammatory diseases.

-20°C,2°C to 8°C

41116100

Mouse