Bio-Connect

Lunacalcipol [250384-82-8]

HY-14863
MedChem Express
CAS Number250384-82-8
Product group Chemicals
Molecular Weight474.70
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Lunacalcipol [250384-82-8]
  • Delivery Days Customer
    5
  • CAS Number
    250384-82-8
  • Certification
    Research Use Only
  • Molecular Formula
    C28H42O4S
  • Molecular Weight
    474.70
  • Scientific Description
    Lunacalcipol (CTA-018), as a vitamin D analogue, has a dual role in the pathogenesis of Chronic Kidney Disease (CKD), as an agonist of vitamin D receptor and an antagonist of cytochrome P450 enzyme 24-hydroxylase. Lunacalcipol binds to VDR and regulates transcriptional activity of VDR by influencing ligand binding affinity, ligand-dependent coactivator recruitment or inhibitory factor dissociation, efficiency of ligand entry into target cells, tissue specificity and different metabolism of ligand. Lunacalcipol can be used in the study of CKD, especially Secondary Hyperparathyroidism (sHPT)[1].
  • SMILES
    C[C@@]12[C@](CC=C2[C@H](C)C/C=C/S(C(C)(C)C)(=O)=O)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C
  • UNSPSC
    12131703