LY-333,531 . hydrochloride [169939-93-9] [169939-93-9]

Bioss

LY-333,531 . hydrochloride [169939-93-9] [169939-93-9]

16

169939-93-9

Research Use Only

Unconjugated

>98%

C28H28N4O3 . HCl

468.6 . 36.5

Isozyme selective inhibitor of protein kinase Cbeta (PKCbeta) [1, 6, 10, 11, 13]. PKCbetaI and PKCbetaII isozyme inhibitor [2-3, 6, 10, 11, 13]. Amelioriates diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy [1, 3, 5-7, 9-11]. Anti-cancer and anti-angiogenic compound [4-5, 8]. Suppresses glucose-induced adhesion of human monocytes to endothelial cells [12]. Suppresses ERK1/2 and Akt phosphorylation [14].

Cl.CN(C)C[C@@H]1CCN2C=C(C3=C2C=CC=C3)C2=C(C(=O)NC2=O)C2=CN(CCO1)C1=C2C=CC=C1

-20°C

12161509