LY-333,531 Hydrochloride [169939-93-9]

Name: LY-333,531 Hydrochloride [169939-93-9]
SKU: SC-364215_1mg_S02
Availability: BackOrder

SC-364215

CAS Number169939-93-9

Product group Chemicals

Overview

Supplier
Santa Cruz Biotechnology
Product Name
LY-333,531 Hydrochloride [169939-93-9]
Delivery Days Customer
5
CAS Number
169939-93-9
Certification
Research Use Only
Scientific Description
LY-333,531 Hydrochloride is a potent and selective inhibitor of protein kinase C (PKC) beta, an enzyme that plays a key role in intracellular signaling pathways. In research applications, this compound is used to investigate the function of PKC beta in various biological processes, including cell proliferation, apoptosis, and angiogenesis. By inhibiting this specific kinase, scientists can dissect the cascade of events that follow PKC beta activation and understand how it affects cellular functions. Moreover, LY-333,531 Hydrochloride is valuable in the study of diabetic complications, as PKC beta has been implicated in the vascular dysfunctions associated with diabetes.
SMILES
CN(C)C[C@@H]1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O.Cl
Storage Instruction
-20°C
UNSPSC
12352200

Miao W, Wu X, Wang K, et al. Sodium butyrate promotes reassembly of tight junctions in caco-2 monolayers involving inhibition of mlck/mlc2 pathway and phosphorylation of pkcβ2. Int J Mol Sci. 2016;17(10):1696.
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Dos Anjos PMF, Volpe CMO, Miranda TC, Nogueira-Machado JA. Atorvastatin inhibited ros generation and increased il-1β and il-6 release by mononuclear cells from diabetic patients. Endocr Metab Immune Disord Drug Targets. 2019;19(8):1207-1215.
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Alshammari RA, Aleanizy FS, Aldarwesh A, et al. Retinal delivery of the protein kinase c-β inhibitor ruboxistaurin using non-invasive nanoparticles of polyamidoamine dendrimers. Pharmaceutics. 2022;14(7):1444.
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