LY 345899

MedChem Express

LY 345899 [10538-99-5]

10

10538-99-5

Research Use Only

98.0

C20H21N7O7

471.42

LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase ( MTHFD1 ; DC301 ) and MTHFD2 inbhibitor with IC 50 values of 96 nM and 663 nM, respectively and a K i of 18 nM for MTHFD1 [1] [2] [3] .

O=C(O)[C@@H](NC(C1=CC=C(N2C(N3C4=C(NC(N)=NC4=O)NCC3C2)=O)C=C1)=O)CCC(O)=O

-20°C

12352200