LY243246 [106400-18-4]

MedChem Express

LY243246 [106400-18-4]

10

106400-18-4

Research Use Only

C21H25N5O6

443.45

LY243246 ((6S)-DDATHF), the 6S diastereomer of DDATHF, is a potent competitive inhibitor of 5-phosphoribosylglycinamide formyltransferase (GAR transformylase). 6R- and 6S-diastereomers of DDATHF are remarkably similar and equiactive antimetabolites inhibitory to de novo purine synthesis[1].

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CC[C@H](CN2)CC3=C2NC(N)=NC3=O)C=C1)=O

12352200