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ProductsBack/LY2886721

LY2886721

M1987

CAS Number1262036-50-9

Product group Chemicals

Molecular Weight390.41

Overview

Supplier
AbMole BioScience
Product Name
LY2886721
Delivery Days Customer
9
CAS Number
1262036-50-9
Certification
Research Use Only
Molecular Formula
C18H16F2N4O2S
Molecular Weight
390.41
Scientific Description
LY2886721 is an effective, selective, orally active inhibitor of beta-site amyloid precursor protein lyase 1 (BACE1) with an IC50 of 20.3 nM against recombinant human BACE1. LY2886721 showed higher selectivity for BACE1 than cathepsin D, pepsin and renin, but lacked selectivity for BACE2 (IC50 was 10.2 nM). LY2886721 crosses the blood-brain barrier and can be used to study Alzheimer's disease.
SMILES
NC1=NC2(COCC2CS1)C3=CC(=CC=C3F)NC(=O)C4=NC=C(F)C=C4
UNSPSC
12352200

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