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LY2886721

M1987
AbMole BioScience
CAS Number1262036-50-9
Product group Chemicals
Molecular Weight390.41
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    LY2886721
  • Delivery Days Customer
    9
  • CAS Number
    1262036-50-9
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Formula
    C18H16F2N4O2S
  • Molecular Weight
    390.41
  • Scientific Description
    LY2886721 is an effective, selective, orally active inhibitor of beta-site amyloid precursor protein lyase 1 (BACE1) with an IC50 of 20.3 nM against recombinant human BACE1. LY2886721 showed higher selectivity for BACE1 than cathepsin D, pepsin and renin, but lacked selectivity for BACE2 (IC50 was 10.2 nM). LY2886721 crosses the blood-brain barrier and can be used to study Alzheimer's disease.
  • SMILES
    NC1=NC2(COCC2CS1)C3=CC(=CC=C3F)NC(=O)C4=NC=C(F)C=C4
  • UNSPSC
    12352200

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