LY303511 hydrochloride [854127-90-5]
T84382
Overview
- SupplierTargetMol Chemicals
- Product NameLY303511 hydrochloride [854127-90-5]
- Delivery Days Customer16
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameLY303511 hydrochloride
- Molecular FormulaC19H20Cl2N2O2
- Molecular Weight379.28
- Scientific DescriptionLY303511, a structural analog of LY294002, selectively inhibits mTOR-dependent phosphorylation of S6K, unlike its counterpart, which acts as a phosphatidylinositol 3-kinase (PI3K) inhibitor. It effectively reduces cell proliferation in human lung epithelial adenocarcinoma cells by hindering G2/M phase progression and suppressing casein kinase 2 activity. Additionally, LY303511 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in HeLa cells resistant to TRAIL-induced apoptosis and blocks voltage-gated potassium (Kv) channels.
- Shelf life instruction3 years
- SMILESCl.Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1
- Storage Instruction-20°C
- UNSPSC12352200