LY3522348
HY-149987
Overview
- SupplierMedChem Express
- Product NameLY3522348 [2568608-48-8]
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity98.91
- Molecular FormulaC18H22F3N7O
- Molecular Weight409.41
- Scientific DescriptionKHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation[1].
- SMILESC[C@@H]1N(CC1)C2=NC(C(F)(F)F)=CC(C3=CN(N=C3)CC(N4CCNCC4)=O)=N2
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12131703