Bio-Connect

LY3522348

HY-149987
MedChem Express
Estimated Purity98.91
Product group Chemicals
Molecular Weight409.41
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Overview

  • Supplier
    MedChem Express
  • Product Name
    LY3522348 [2568608-48-8]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    98.91
  • Molecular Formula
    C18H22F3N7O
  • Molecular Weight
    409.41
  • Scientific Description
    KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation[1].
  • SMILES
    C[C@@H]1N(CC1)C2=NC(C(F)(F)F)=CC(C3=CN(N=C3)CC(N4CCNCC4)=O)=N2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12131703