Lys05 [1391426-24-6]

TargetMol Chemicals

Lys05 [1391426-24-6]

4

1391426-24-6

Chemical

Research Use Only

Lys05

99.23%

C23H26Cl5N5

549.75

Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models compared with HCQ. Lys05 is therefore a new lysosomal autophagy inhibitor that has potential to be developed further into a drug for cancer and other medical applications.

3 years

Cl.Cl.Cl.CN(CCNc1ccnc2cc(Cl)ccc12)CCNc1ccnc2cc(Cl)ccc12

-20°C

12352200