Macozinone

MedChem Express

Macozinone [1377239-83-2]

5

1377239-83-2

Research Use Only

98.46

C20H23F3N4O3S

456.48

Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-beta-d-ribose 2-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect [1] [2] .

O=C1C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2SC(N3CCN(CC4CCCCC4)CC3)=N1

-20°C,2°C to 8°C

12352200