MAFB Antibody

Cusabio

MAFB Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

MAFB

MAF bZIP transcription factor B

DURS3, KRML, MCTO, transcription factor MafB, Kreisler maf-related leucine zipper homolog, MAFB/Kreisler basic region/leucine zipper transcription factor, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B

Rabbit

IgG

Transcription factor MafB

Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.

Human, Mouse

-20°C or -80°C

41116161