MAGL-IN-12 [1352011-38-1]
HY-116143
CAS Number1352011-38-1
Product group Chemicals
Molecular Weight482.83
Overview
- SupplierMedChem Express
- Product NameMAGL-IN-12 [1352011-38-1]
- Delivery Days Customer14
- CAS Number1352011-38-1
- CertificationResearch Use Only
- Molecular FormulaC16H17ClF6N2O4S
- Molecular Weight482.83
- Scientific DescriptionSAR127303 is an orally active, selective, competitive monoacylglycerol lipase (MAGL) covalent inhibitor with IC50s of 3.8 nM and 29 nM for mouse and human MAGL, respectively. SAR127303 potently elevates hippocampal levels of 2-AG in mice. SAR127303 decreased long term potentiation (LTP) of CA1 synaptic transmission and acetylcholine release in the hippocampus. SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. SAR127303 slows down epileptogenesis[1].
- SMILESClC1=CC=C(C=C1)S(NCC2CCN(CC2)C(OC(C(F)(F)F)C(F)(F)F)=O)(=O)=O
- UNSPSC12352200