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ProductsBack/Magnolol [528-43-8]
Chemical Structure
Chemical Structure
Chemical Structure

Magnolol [528-43-8]

CDX-M0170
Chemodex
CAS Number528-43-8
DownloadDatasheet
Product group Chemicals
Estimated Purity>98%
Molecular Weight266.33
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Overview

  • Supplier
    Chemodex
  • Product Name
    Magnolol [528-43-8]
  • Delivery Days Customer
    10
  • CAS Number
    528-43-8
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C18H18O2
  • Molecular Weight
    266.33
  • Scientific Description
    Chemical. CAS: 528-43-8. Formula: C18H18O2. MW: 266.33. Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol is an antifungal, antibacterial and antioxidant compound. It demonstrates anti-inflammatory activity by interferring with NF-kappaB signalling and NLRP3 inhibition. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype versus central CB1. It been identified as modulators of the GABAA receptors in vitro. It is a potent antitumor and antiangiogenic compound. Shown to inhibit HIF-1alpha/VEGF signalling, inhibiting invasion and metastasis through MMP2/MMP9 and inhibiting microtubule polymerization. Induces apoptosis through EGFR/PI3K/Akt pathway. Shows anti-diabetic/anti-obesity activity targeting nuclear receptors retinoic X receptor alpha (RXRalpha) and peroxisome proliferator activated receptor gamma (PPARgamma). In addition promotes thermogenesis. - Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol is an antifungal, antibacterial and antioxidant compound. It demonstrates anti-inflammatory activity by interferring with NF-kappaB signalling and NLRP3 inhibition. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype versus central CB1. It been identified as modulators of the GABAA receptors in vitro. It is a potent antitumor and antiangiogenic compound. Shown to inhibit HIF-1alpha/VEGF signalling, inhibiting invasion and metastasis through MMP2/MMP9 and inhibiting microtubule polymerization. Induces apoptosis through EGFR/PI3K/Akt pathway. Shows anti-diabetic/anti-obesity activity targeting nuclear receptors retinoic X receptor alpha (RXRalpha) and peroxisome proliferator activated receptor gamma (PPARgamma). In addition promotes thermogenesis.
  • SMILES
    OC1=CC=C(CC=C)C=C1C2=CC(CC=C)=CC=C2O
  • Storage Instruction
    2°C to 8°C
  • UN Number
    3077
  • UNSPSC
    12352200