Mahanine [28360-49-8]

TargetMol Chemicals

Mahanine [28360-49-8]

16

28360-49-8

Chemical

Research Use Only

Mahanine

C23H25NO2

347.458

Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can reverse an epigenetically silenced gene, RASSF1A in prostate cancer cells by inhibiting DNMT activity that in turn down-regulates a key cell cycle regulator, cyclin D1, is an encouraging therapeutic choice for advanced prostatic cancer.

3 years

CC(C)=CCC[C@@]1(C)Oc2c(C)cc3c([nH]c4cc(O)ccc34)c2C=C1 - wU:6.6,wD:6.5,c:27,(12.99,-4.96,;11.75,-4.04,;10.34,-4.65,;11.93,-2.51,;10.7,-1.59,;10.88,-.06,;9.65,.86,;10.77,1.91,;8.8,2.15,;7.26,2.06,;6.42,3.35,;7.11,4.72,;4.88,3.26,;4.19,1.88,;5.03,.59,;4.07,-.61,;2.63,-.06,;1.26,-.77,;-.04,.06,;-1.4,-.64,;.04,1.6,;1.41,2.31,;2.7,1.48,;6.57,.68,;7.42,-.61,;8.95,-.52,) -

-20°C

12352200