Mal-amide-PEG8-Val-Cit-PAB-OH

MedChem Express

Mal-amide-PEG8-Val-Cit-PAB-OH [2387738-43-2]

5

Research Use Only

C44H71N7O16

954.07

Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker featuring a maleimide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB functional group. Maleimide is used to covalently bind free thiols on the cysteine residues of proteins. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery with the help of the PAB structure.

CC(C)[C@@H](C(N[C@H](C(NC1=CC=C(C=C1)CO)=O)CCCNC(N)=O)=O)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN(C(C=C2)=O)C2=O)=O)=O

41115800