Mal-amide-PEG8-Val-Cit-PAB-PNP

MedChem Express

Mal-amide-PEG8-Val-Cit-PAB-PNP

5

Research Use Only

C51H74N8O20

1119.17

Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker featuring a maleimide, a PEG spacer, a Val-Cit dipeptide, a PAB. and a PNP carbonate. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the PNP group acts as a highly activated leaving group. Val-Cit linkers are cleaved by cytoplasmic peptidases.

O=C(C=CC1=O)N1CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(C=C2)COC(OC3=CC=C(C=C3)[N+]([O-])=O)=O)=O)=O)=O)=O

41115800