Mal-VC-PAB-EDA-N-Ac-Calicheamicin

MedChem Express

Mal-VC-PAB-EDA-N-Ac-Calicheamicin

5

Research Use Only

C93H128IN11O31S3

2119.17

Mal-VC-PAB-EDA-N-Ac-Calicheamicin is a Drug-Linker Conjugate for ADC with potent antitumor activity. OncoFAP-GlyPro-MMAF consists of ADC toxin Calicheamicin (HY-19609) and a linker. OncoFAP-GlyPro-MMAF can be used for synthesis of ADC, PF-06647263 (HY-111965)[1].

O=C(C1=C(C(OC)=C(C(I)=C1C)O[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)OC)O)OC)S[C@@H]3[C@H](O[C@H](C[C@@H]3O)ON[C@@H]4[C@H](OC([C@@H]([C@H]4O)O[C@H]5C[C@@H]([C@H](CO5)N(CC)C(C)=O)OC)O[C@H](C(/C6=C\CSSC(C)(C)CCC(NCCNC(OCC7=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN8C(C=CC8=O)=O)=O)=O)=O)C=C7)=O)=O)=C9NC(OC)=O)C#C/C=C\C#C[C@]6(CC9=O)O)C)C

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