Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-beta-Glu-PAB-Exatecan

MedChem Express

Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-beta-Glu-PAB-Exatecan

5

Research Use Only

96.11

C87H118FN9O34

1852.91

Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-beta-Glu-PAB-Exatecan (LP1) is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor Exatecan (HY-13631) and a linker Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-beta-Glu-PAB (HY-173635) to make antibody agent conjugate (ADC), AZD0516 (HY-173639)[1].

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5NC(OCC7=CC=C(O[C@@H]8O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]8O)C(CNC(CCNC([C@@H](NC(CCN9C(C=CC9=O)=O)=O)CCCC(N[C@@H]%10[C@@H](OC[C@@H]%11NC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)[C@@H]%11OC%10)=O)=O)=O)=C7)=O)C(C)=C(F)C=C6N=C4C3=C2)=O

-20°C

41115800