MALT1 antibody [SPM578]

GeneTex

MALT1 antibody [SPM578]

9

WB: 1-2microg/ml. IHC-P: 1-2microg/ml for 30 minutes at RT. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

SPM578

0.2 mg/ml

Unconjugated

MALT1

MALT1 paracaspase

caspase-like protein; IMD12; MALT1 protease; MLT; MLT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; mucosa-associated lymphoid tissue lymphoma translocation protein 1; paracaspase-1; PCASP1

Mouse

IgG1

Mucosa-associated lymphoid tissue lymphoma translocation protein 1

This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018]

Human

-20°C or -80°C,2°C to 8°C

12352203