Manumycin A

MedChem Express

Manumycin A [52665-74-4]

10

52665-74-4

Research Use Only

99.27

C31H38N2O7

550.64

Manumycin A is a polyketide antibiotic and an inhibitor of thioredoxin reductase 1 ( TrxR-1 ). Manumycin A can inhibit the growth of breast cancer cells and exert its anti-tumor activity through LC3 . Manumycin A can downregulate the release of pro-inflammatory cytokines in human monocytes stimulated by TNF alpha , and has potential anti-inflammatory activity. Manumycin A can inhibit the Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration resistant prostate cancer cells to suppress exosome biogenesis and secretion [1] [3] [4] .

CCCC[C@@H](C)/C=C(C)/C=C(C)/C(NC1=C[C@](/C=C/C=C/C=C/C(NC2=C(O)CCC2=O)=O)(O)[C@]3([H])O[C@]3([H])C1=O)=O

-20°C

12352200