Bio-Connect
Chemical Structure
Chemical Structure
Chemical Structure

Manumycin A [25394-57-4]

Research Use Only
AG-CN2-2000
AdipoGen Life Sciences
CAS Number25394-57-4
Product group Chemicals
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Manumycin A
  • Delivery Days Customer
    10
  • CAS Number
    25394-57-4
  • Certification
    Research Use Only
  • Scientific Description
    Antibiotic. Apoptosis and endoplasmic reticulum stress-mediated cell death inducer. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM). Does not affect geranylgeranyltransferase (IC50 = 180 microM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19 microM). Targets protein phosphatase 1alpha (PP1alpha) and reduces hydrogen peroxide. Corrects aberrant splicing of the muscle chloride channel Clcn1 in myotonic dystrophy type 1 (DM1). Shows potential anti-inflammatory activity. Irreversible human thioredoxin reductase 1 (TrxR-1) inhibitor (IC50=272nM) and inducer of NADPH oxidase activity. Acts very likely as a Michael acceptor to the nucleophilic Sec residue in the C-terminal redox center of TrxR-1 which yields a SecTRAP (selenium compromised thioredoxin reductase-derived apoptotic proteins), which promotes both apoptosis and necrosis via oxidative stress and increased intracellular reactive oxygen species (ROS) production. Due to the involvement of Ras during exosomes release, manumycin A has been investigated as an inhibitor of exosomes secretion. Acts against myotonic dystrophy type 1 (DM1). Mediates lymphoma apoptosis by targeting protein phosphatase 1alpha. - Chemical. CAS: 52665-74-4. Formula: C31H38N2O7. MW: 550.6. Antibiotic. Apoptosis and endoplasmic reticulum stress-mediated cell death inducer. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM). Does not affect geranylgeranyltransferase (IC50 = 180 microM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19 microM). Targets protein phosphatase 1alpha (PP1alpha) and reduces hydrogen peroxide. Corrects aberrant splicing of the muscle chloride channel Clcn1 in myotonic dystrophy type 1 (DM1). Shows potential anti-inflammatory activity. Irreversible human thioredoxin reductase 1 (TrxR-1) inhibitor (IC50=272nM) and inducer of NADPH oxidase activity. Acts very likely as a Michael acceptor to the nucleophilic Sec residue in the C-terminal redox center of TrxR-1 which yields a SecTRAP (selenium compromised thioredoxin reductase-derived apoptotic proteins), which promotes both apoptosis and necrosis via oxidative stress and increased intracellular reactive oxygen species (ROS) production. Due to the involvement of Ras during exosomes release, manumycin A has been investigated as an inhibitor of exosomes secretion. Acts against myotonic dystrophy type 1 (DM1). Mediates lymphoma apoptosis by targeting protein phosphatase 1alpha.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

Related products

Product group Chemicals
Key Organics
CAS Number1341405-19-3
Estimated Purity>97%
  • SizePrice
Product group Chemicals
Key Organics
CAS Number1339586-51-4
Estimated Purity>97%
  • SizePrice
Product group Chemicals
Key Organics
CAS Number1352925-43-9
Estimated Purity>95%
  • SizePrice
Product group Chemicals
Key Organics
CAS Number1206641-15-7
Estimated Purity>97%
  • SizePrice
Product group Chemicals
Key Organics
CAS Number1357147-44-4
Estimated Purity>95%
  • SizePrice
Product group Chemicals
Key Organics
CAS Number33797-34-1
Estimated Purity>97%
  • SizePrice
Product group Chemicals
Key Organics
CAS Number85330-50-3
Estimated Purity>95%
  • SizePrice
Product group Chemicals
Key Organics
CAS Number1206640-61-0
Estimated Purity>95%
  • SizePrice
Product group Chemicals
Key Organics
CAS Number1340396-26-0
Estimated Purity>97%
  • SizePrice
Product group Chemicals
Key Organics
CAS Number927802-18-4
Estimated Purity>97%
  • SizePrice