Bio-Connect

Manzamine A [104196-68-1]

HY-117025
MedChem Express
CAS Number104196-68-1
Product group Chemicals
Estimated Purity98.2
Molecular Weight548.76
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    MedChem Express
  • Product Name
    Manzamine A [104196-68-1]
  • Delivery Days Customer
    10
  • CAS Number
    104196-68-1
  • Certification
    Research Use Only
  • Estimated Purity
    98.2
  • Molecular Formula
    C36H44N4O
  • Molecular Weight
    548.76
  • Scientific Description
    Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3beta and CDK-5 with IC50s of 10.2 microM and 1.5 microM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1[1][2][3][4].
  • SMILES
    O[C@]1(CC/C=C\CCCC2)[C@@]3([H])[C@@](C[C@@]4([H])N3CCCC/C=C\4)(C[N@@]2CC5)[C@]5([H])C(C6=C(NC7=CC=CC=C87)C8=CC=N6)=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200