MAO A/HSP90-IN-2 [2927489-99-2]
HY-155580
CAS Number2927489-99-2
Product group Chemicals
Molecular Weight458.98
Overview
- SupplierMedChem Express
- Product NameMAO A/HSP90-IN-2 [2927489-99-2]
- Delivery Days Customer14
- CAS Number2927489-99-2
- CertificationResearch Use Only
- Molecular FormulaC25H31ClN2O4
- Molecular Weight458.98
- Scientific DescriptionMAO A/HSP90-IN-2 (compound 4-C) is a dual inhibitor of HSP90and MAO A with the IC50 values of 0.016 and 4.58 microM, respectively. MAO A/HSP90-IN-2 increases HSP70 expression and reduces HER2 and phospho-Akt expression, and decreases IFN-gamma induced PD-L1 expression in GL26 cells. MAO A/HSP90-IN-2 inhibits the growth of Temozolomide (HY-17364) -sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung and other cancers, and has potential to inhibit tumor immune escape[1].
- SMILESO=C(C1=C(C=C(C(C(C)C)=C1)O)O)N(C2=CC(Cl)=C(C=C2)OCCCN(CC#C)C)CC
- UNSPSC12352200