MAO A/HSP90-IN-2

Biorbyt

MAO A/HSP90-IN-2

10

Research Use Only

98.00%

C25H31ClN2O4

458.98

MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 microM for MAO A and 4.58 microM for HSP90. This compound enhances HSP70 expression, diminishes HER2 and phospho-Akt levels, downregulates IFN-gamma-induced PD-L1 expression in GL26 cells, and demonstrates efficacy against Temozolomide-sensitive and -resistant GBM cells, colon cancer, leukemia, and non-small cell lung cancer, possibly impeding tumor immune evasion [1].

C(N(CC)C1=CC(Cl)=C(OCCCN(CC#C)C)C=C1)(=O)C2=CC(C(C)C)=C(O)C=C2O

-20°C

12352200