MAO-B-IN-46

MedChem Express

MAO-B-IN-46

999

Research Use Only

C15H9ClO2

256.68

MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC50: 26.8 nM), with weak activity against hMAO-A (IC50: 7.2054 microM). MAO-B-IN-46 (Compound 8) also acts as an alpha-amylase inhibitor (IC50: 19.46 microM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 microM and 17.71 microM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinsons disease, diabetes, and diseases related to oxidative stress resistance[1][2].

C1=CC=C2C(=C1)C=C(C(=O)C3=CC=C(C=C3)Cl)O2

12352200