MAP2K4 Antibody

Cusabio

MAP2K4 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

MAP2K4

mitogen-activated protein kinase kinase 4

c-Jun N-terminal kinase kinase 1; dual specificity mitogen-activated protein kinase kinase 4; JNK-activated kinase 1; JNK-activating kinase 1; JNKK; JNKK1; MAP kinase kinase 4; MAPK/ERK kinase 4; MAPKK 4; MAPKK4; MEK 4; MEK4; MKK4; PRKMK4; SAPK/ERK kinase 1; SAPKK1; SAPKK-1; SEK1; SERK1; SKK1; stress-activated protein kinase kinase 1

Rabbit

IgG

Dual specificity mitogen-activated protein kinase kinase 4

SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop (4). Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction (5). Davis, R.J. (1994) Trends Biochem. Sci. 19, 470-473. Sanchez, I. et al. (1994) Nature 372, 794-798. Yan, M. et al. (1994) Nature 372, 798-800. Kyriakis, J.M. et al. (1994) Nature 369, 156-160. Park, H. et al. (2002) J. Biol. Chem. 277, 2573-2578.

Human

-20°C or -80°C

12352203