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Western blot detection of NIK in 1, macrophage and 2, NIK transfected cells by anti-human NIK.
Western blot detection of NIK in 1, macrophage and 2, NIK transfected cells by anti-human NIK.
Western blot detection of NIK in 1, macrophage and 2, NIK transfected cells by anti-human NIK.

MAP3K14 antibody

GTX27204
GeneTex
Product group Antibodies
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Overview

  • Supplier
    GeneTex
  • Product Name
    MAP3K14 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    IP: Use at a dilution of 1/500. WB: Use at a dilution of 1/2000. Optimal dilutions/concentrations should be determined by the end user.
  • Concentration
    1 mg/ml
  • Formulation
    Liquid
  • Scientific Description
    NIK (NF-kB-inducing kinase) is a member of the MAP kinase kinase kinase family that binds TRAF2 and stimulates NF-kB activity. NIK, initially isolated from a human B cell cDNA library, contains 795 amino acids with an apparent molecular weight of slightly more than 97 kDa on SDS gel. NIK is a serine/threonine kinase and its kinase activity contributes to I B phosphorylation. The carboxyl terminal segment of NIK binds TRAF2. A mutant NIK with intact carboxyl terminus but without the two lysine residues at its catalytic domain serves as a dominant-negative inhibitor for NF-kB activation. NIK also interacts with TRAF6 and mediates IL-1-induced NF-kB activation.
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203