MAP3K5 Polyclonal Antibody

Reddot Biotech

MAP3K5 Polyclonal Antibody

5

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

MAP3K5

mitogen-activated protein kinase kinase kinase 5

ASK1, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5, ASK-1, MAP/ERK kinase kinase 5, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5, apoptosis signal-regulating kinase 1

Rabbit

IgG

Mitogen-activated protein kinase kinase kinase 5

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. - This is a MAP3K5 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

-20°C

41116161