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MAP3K8/TPL-2, Human (sf9, GST)

Name: MAP3K8/TPL-2, Human (sf9, GST)
SKU: HY-P75921_M09
Availability: BackOrder

HY-P75921

Protein IDP41279

Product group Proteins / Signaling Molecules

Overview

Supplier
MedChem Express
Product Name
MAP3K8/TPL-2, Human (sf9, GST)
Delivery Days Customer
10
Certification
Research Use Only
Gene ID1326
Target name
MAP3K8
Target description
mitogen-activated protein kinase kinase kinase 8
Target synonyms
AURA2, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT, mitogen-activated protein kinase kinase kinase 8, Ewing sarcoma transformant, augmented in rheumatoid arthritis 2, cot (cancer Osaka thyroid) oncogene, proto-oncogene c-Cot, proto-oncogene serine/threoine protein kinase, tumor progression locus 2
Protein IDP41279
Protein Name
Mitogen-activated protein kinase kinase kinase 8
Scientific Description
MAP3K8/TPL-2 is critical for LPS-induced, TLR4-mediated activation of MAPK/ERK, leading to TNF production by macrophages. It regulates T cell differentiation, IFNG expression, and host resistance to bacterial infections by negatively regulating type I interferon production. MAP3K8/TPL-2 Protein, Human (sf9, GST) is the recombinant human-derived MAP3K8/TPL-2 protein, expressed by Sf9 insect cells , with N-GST labeled tag.
UNSPSC
41116100