MAPK-IN-2

TargetMol Chemicals

MAPK-IN-2

16

Chemical

Research Use Only

MAPK-IN-2

C20H11Cl2N3O

380.23

MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cell lines. It demonstrates robust suppression of the MAPK pathway (EGFR WT IC50 = 281 nM, c-MET IC50 = 205 nM, B-RAF WT IC50 = 112 nM, CDK4/6 IC50 = 95 and 184 nM, respectively) and exhibits pronounced activity against mutated forms of EGFR and B-RAF (EGFR T790M IC50 = 69 nM and B-RAF V600E IC50 = 83 nM) [1].

3 years

ClC1=CC=C(C(C=C(C2=CNC3=C2C=CC=C3)N4)=C(C#N)C4=O)C(Cl)=C1

-20°C

51202000