Masitinib

MedChem Express

Masitinib [790299-79-5]

10

790299-79-5

Research Use Only

99.98

C28H30N6OS

498.64

Masitinib (AB1010) is a potent, orally bioavailable, and selective inhibitor of c-Kit ( IC 50 =200 nM for human recombinant c-Kit). It also inhibits PDGFRalpha/beta ( IC 50 s=540/800 nM), Lyn ( IC 50 = 510 nM for LynB), Lck , and, to a lesser extent, FGFR3 and FAK . Masitinib (AB1010) has anti-proliferative, pro-apoptotic activity and low toxicity [1] [2] [4] .

O=C(NC1=CC=C(C(NC2=NC(C3=CC=CN=C3)=CS2)=C1)C)C4=CC=C(CN5CCN(CC5)C)C=C4

-20°C,2°C to 8°C

12352200