Mazdutide [2259884-03-0]

AdipoGen Life Sciences

Mazdutide [2259884-03-0]

10

2259884-03-0

Research Use Only

>98%

C210H322N46O67

4563.1

Chemical. CAS: 2259884-03-0. Formula: C210H322N46O67. MW: 4563.1. Soluble in water or DMSO (both 1mg/ml). Mazdutide is a novel long-acting dual glucagon-like peptide-1 (GLP-1) receptor and glucagon receptor (GCGR) agonist. Mazdutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GCG receptor (GCGR) or the GLP-1R. Mazdutide is a synthetic peptide analog of the gut peptide hormone oxyntomodulin that reduces body weight in both Gcgr-/- and Glp1r-/- mice. Mazdutide binds human and mouse GCGR (Ki: 17.7nM and 15.9nM, respectively) and GLP-1R (Ki: 28.6nM and 25.1nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D) and is designed enhancing energy expenditure and fat metabolism. Mazdutide comprises a 33 amino acid linear synthetic peptide conjugated to a C20 fatty diacid moiety through a hydrophilic linker at the lysine residue at position 20. Due to this moiety, the compound is highly bound to albumin in the plasma which prolongs its half-life. It contains one non-coded amino acid residue (Aib, alpha-amino isobutyric acid) at position 2. - Mazdutide is a novel long-acting dual glucagon-like peptide-1 (GLP-1) receptor and glucagon receptor (GCGR) agonist. Mazdutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GCG receptor (GCGR) or the GLP-1R. Mazdutide is a synthetic peptide analog of the gut peptide hormone oxyntomodulin that reduces body weight in both Gcgr-/- and Glp1r-/- mice. Mazdutide binds human and mouse GCGR (Ki: 17.7nM and 15.9nM, respectively) and GLP-1R (Ki: 28.6nM and 25.1nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D) and is designed enhancing energy expenditure and fat metabolism. Mazdutide comprises a 33 amino acid linear synthetic peptide conjugated to a C20 fatty diacid moiety through a hydrophilic linker at the lysine residue at position 20. Due to this moiety, the compound is highly bound to albumin in the plasma which prolongs its half-life. It contains one non-coded amino acid residue (Aib, alpha-amino isobutyric acid) at position 2.

O=C(N)CNC([C@H](CO)NC([C@H](CO)NC([C@H]1N(C(CNC(CNC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC([C@H](CC4=CC=CC=C4)NC([C@H](CCC(O)=O)NC([C@H](CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@H](NC(CCCCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)=O)=O)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC5=CC=C(O)C=C5)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC6=CC=C(O)C=C6)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC7=CC=CC=C7)NC([C@H]([C@H](O)C)NC(CNC([C@H](CCC(N)=O)NC(C(C)(C)NC([C@H](CC8=CNC=N8)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)=O)=O)=O

-20°C,2°C to 8°C

12352200