Mc-Val-Cit-PAB-Cl [1639351-92-0]

TargetMol Chemicals

Mc-Val-Cit-PAB-Cl [1639351-92-0]

4

1639351-92-0

Chemical

Research Use Only

Mc-Val-Cit-PAB-Cl

99.79%

C28H39ClN6O6

591.1

Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively.

3 years

[C@@H](NC([C@@H](NC(CCCCCN1C(=O)C=CC1=O)=O)[C@H](C)C)=O)(C(NC2=CC=C(CCl)C=C2)=O)CCCNC(N)=O

-20°C

12352200