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MCL1 antibody

GTX102026
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetMCL1
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Overview

  • Supplier
    GeneTex
  • Product Name
    MCL1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.33 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4170
  • Target name
    MCL1
  • Target description
    MCL1 apoptosis regulator, BCL2 family member
  • Target synonyms
    BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, induced myeloid leukemia cell differentiation protein Mcl-1, BCL2 family apoptosis regulator, MCL1, BCL2 family apoptosis regulator, bcl-2-like protein 3, bcl-2-related protein EAT/mcl1, myeloid cell leukemia 1, myeloid cell leukemia ES, myeloid cell leukemia sequence 1 (BCL2-related)
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ07820
  • Protein Name
    Induced myeloid leukemia cell differentiation protein Mcl-1
  • Scientific Description
    The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Chen SM, Hee SW, Chou SY, et al. Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells. Biomolecules. 2021,11(10). doi: 10.3390/biom11101474
    Read this paper
  • Takino JI, Sato T, Nagamine K, et al. The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells. Sci Rep. 2019,9(1):16717. doi: 10.1038/s41598-019-53419-4
    Read this paper
  • Chen PY, Tien HJ, Chen SF, et al. Response of Myeloid Leukemia Cells to Luteolin is Modulated by Differentially Expressed Pituitary Tumor-Transforming Gene 1 (PTTG1) Oncoprotein. Int J Mol Sci. 2018,19(4). doi: 10.3390/ijms19041173
    Read this paper
  • Sharikova AV, Quaye E, Park JY, et al. Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway. J Neuroimmune Pharmacol. 2018,13(3):396-411. doi: 10.1007/s11481-018-9787-4
    Read this paper
  • Lee WY, Chen PC, Wu WS, et al. Panobinostat sensitizes KRAS-mutant non-small-cell lung cancer to gefitinib by targeting TAZ. Int J Cancer. 2017,141(9):1921-1931. doi: 10.1002/ijc.30888
    Read this paper
  • Chen PH, Shen WL, Shih CM, et al. The CHAC1-inhibited Notch3 pathway is involved in temozolomide-induced glioma cytotoxicity. Neuropharmacology. 2017,116:300-314. doi: 10.1016/j.neuropharm.2016.12.011
    Read this paper
  • Urbán N, van den Berg DL, Forget A, et al. Return to quiescence of mouse neural stem cells by degradation of a proactivation protein. Science. 2016,353(6296):292-5. doi: 10.1126/science.aaf4802
    Read this paper
  • Peng HY, Cheng YC, Hsu YM, et al. MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma. PLoS One. 2016,11(7):e0158440. doi: 10.1371/journal.pone.0158440
    Read this paper
  • Lee WY, Lee WT, Cheng CH, et al. Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. Oncotarget. 2015,6(29):27580-95. doi: 10.18632/oncotarget.4768
    Read this paper
  • Lin MH, Cheng CH, Chen KC, et al. Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells. Chem Biol Interact. 2014,218:42-9. doi: 10.1016/j.cbi.2014.04.015
    Read this paper

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Figure 1. Western blot analysis of MCL1 using anti-MCL1 antibody (A00712-2). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human Raji whole cell lysates, Lane 2: human Ramos whole cell lysates, Lane 3: human MCF-7 whole cell lysates, Lane 4: human K562 whole cell lysates, Lane 5: rat stomach tissue lysates, Lane 6: rat kisney tissue lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-MCL1 antigen affinity purified polyclonal antibody (Catalog # A00712-2) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for MCL1 at approximately 40 kDa. The expected band size for MCL1 is at 28,37,40 kDa.
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