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MCL1 antibody

GTX102026
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
TargetMCL1
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Overview

  • Supplier
    GeneTex
  • Product Name
    MCL1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.33 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4170
  • Target name
    MCL1
  • Target description
    MCL1 apoptosis regulator, BCL2 family member
  • Target synonyms
    BCL2 family apoptosis regulator; BCL2L3; bcl2-L-3; bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; EAT; induced myeloid leukemia cell differentiation protein Mcl-1; Mcl-1; MCL1, BCL2 family apoptosis regulator; mcl1/EAT; MCL1-ES; MCL1L; MCL1S; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1 (BCL2-related); TM
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ07820
  • Protein Name
    Induced myeloid leukemia cell differentiation protein Mcl-1
  • Scientific Description
    The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells. Chen SM et al., 2021 Oct 6, Biomolecules
    Read more
  • The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells. Takino JI et al., 2019 Nov 13, Sci Rep
    Read more
  • Response of Myeloid Leukemia Cells to Luteolin is Modulated by Differentially Expressed Pituitary Tumor-Transforming Gene 1 (PTTG1) Oncoprotein. Chen PY et al., 2018 Apr 12, Int J Mol Sci
    Read more
  • Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway. Sharikova AV et al., 2018 Sep, J Neuroimmune Pharmacol
    Read more
  • Panobinostat sensitizes KRAS-mutant non-small-cell lung cancer to gefitinib by targeting TAZ. Lee WY et al., 2017 Nov 1, Int J Cancer
    Read more
  • The CHAC1-inhibited Notch3 pathway is involved in temozolomide-induced glioma cytotoxicity. Chen PH et al., 2017 Apr, Neuropharmacology
    Read more
  • Return to quiescence of mouse neural stem cells by degradation of a proactivation protein. Urban N et al., 2016 Jul 15, Science
    Read more
  • MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma. Peng HY et al., 2016, PLoS One
    Read more
  • Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. Lee WY et al., 2015 Sep 29, Oncotarget
    Read more
  • Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells. Lin MH et al., 2014 Jul 25, Chem Biol Interact
    Read more

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Figure 1. Western blot analysis of MCL1 using anti-MCL1 antibody (A00712-2). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human Raji whole cell lysates, Lane 2: human Ramos whole cell lysates, Lane 3: human MCF-7 whole cell lysates, Lane 4: human K562 whole cell lysates, Lane 5: rat stomach tissue lysates, Lane 6: rat kisney tissue lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-MCL1 antigen affinity purified polyclonal antibody (Catalog # A00712-2) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for MCL1 at approximately 40 kDa. The expected band size for MCL1 is at 28,37,40 kDa.
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