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Mcl1-IN-9

Mcl1-IN-9

T11977
TargetMol Chemicals
CAS Number1810769-31-3
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Product group Chemicals
Molecular Weight639.18
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Mcl1-IN-9
  • Delivery Days Customer
    65
  • CAS Number
    1810769-31-3
  • Category Supplier
    Chemical
  • Chemical Name
    Mcl1-IN-9
  • Molecular Formula
    C37H39ClN4O4
  • Molecular Weight
    639.18
  • Scientific Description
    Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.
  • Shelf life instruction
    3 years
  • SMILES
    C(CCOC1=CC(C)=C(Cl)C(C)=C1)C=2C=3C(N4C2C(=O)N(CC5=CC(C(O)=O)=CC=C5)CCC4)=C(C=CC3)C=6C(C)=NN(C)C6C
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Lee T, et al, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem. 2019 Apr 25;62(8):3971-3988.
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