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MCU-i4

ORB1089572
Biorbyt
CAS Number371924-24-2
Product group Chemicals
Molecular Weight377.48
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Overview

  • Supplier
    Biorbyt
  • Product Name
    MCU-i4 [371924-24-2]
  • Delivery Days Customer
    10
  • CAS Number
    371924-24-2
  • Certification
    Research Use Only
  • Molecular Formula
    C23H27N3O2
  • Molecular Weight
    377.48
  • Scientific Description
    MCU-i4 is a negative modulator of the mitochondrial calcium uniporter (MCU) complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx.,MCU-i4 decreases mitochondrial Ca2+ influx. Docking simulations reveal that MCU-i4 directly binds a specific cleft in MICU1, a key element of the MCU complex that controls channel gating. Accordingly, in MICU1-silenced or deleted cells, the inhibitory effect of MCU-i4 is lost. Moreover, MCU-i4 fails to inhibit mitochondrial Ca2+ uptake in cells expressing a MICU1 mutated in the critical amino acids that forge the predicted binding cleft.[1]
  • SMILES
    O=C(C1=C(NC2=CC=C(N(CC)CC)C=C2)C3=CC(C)=CC=C3N=C1)OCC
  • UNSPSC
    12352200

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