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MCUF-651

ORB1785952
Biorbyt
Molecular Weight368.447
Product group Chemicals
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Overview

  • Supplier
    Biorbyt
  • Product Name
    MCUF-651
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Molecular Formula
    C17H22F2N4OS
  • Molecular Weight
    368.447
  • Scientific Description
    MCUF-651 (MCUF651) is a small molecule guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM), potentiate ANP-mediated cGMP with EC50 of 0.45 uM (Emax=82%) in HEK293 GC-A cells.MCUF-651 enhanced ANP-mediated cGMP generation in human cardiac, renal, and fat cells and inhibited cardiomyocyte hypertrophy in vitro.MCUF-651 binds to GC-A (Kd=397 nM) and selectively enhances the binding of ANP to GC-A ( MCUF-651+ANP, Kd=0.06 nM).MCUF-651 is orally bioavailable in mice and enhances the ability of endogenous ANP and BNP to generate GC-A-mediated cGMP ex vivo.
  • SMILES
    O=C(C1CN(CCN(C)C)CCC1)NC2=NC3=C(F)C=C(F)C=C3S2
  • UNSPSC
    12352200