MD2 antibody [1A2E3]

GeneTex

MD2 antibody [1A2E3]

9

WB: 1 microg/mL. IHC-P: 2.5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

1A2E3

1 mg/ml

Unconjugated

LY96

lymphocyte antigen 96

ESOP-1; ly-96; lymphocyte antigen 96; MD2; MD-2; myeloid differentiation protein-2; protein MD-2

Mouse

IgG1

Lymphocyte antigen 96

MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203