MD2-TLR4-IN-1 [2249801-12-3]

MedChem Express

MD2-TLR4-IN-1 [2249801-12-3]

10

2249801-12-3

Research Use Only

99.62

C22H14Cl2N4O

421.28

MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 microM and 0.53 microM, respectively[1].

ClC1=C(C(NC2=CC(C(C3=CC=C(NC=C4)C4=C3)=NN5)=C5C=C2)=O)C(Cl)=CC=C1

-20°C,2°C to 8°C

12352200