MDC1 antibody [N2N3]

GeneTex

MDC1 antibody [N2N3]

9

WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

MDC1

mediator of DNA damage checkpoint 1

NFBD1, mediator of DNA damage checkpoint protein 1, homologue to Drosophila photoreceptor protein calphotin, nuclear factor with BRCT domains 1

Rabbit

IgG

Mediator of DNA damage checkpoint protein 1

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq]

Human

-20°C or -80°C,2°C to 8°C

12352203